B Positive

B Positive is a CBS multi-camera comedy centered on Drew, a newly divorced therapist and dad whose life takes a major turn when he suddenly needs a kidney donor. The answer arrives in the form of Gina, an old high school acquaintance from his past, who unexpectedly volunteers to donate her kidney. That unlikely arrangement pushes the two into an awkward, funny, and deeply personal relationship as they navigate surgery, recovery, family, and the emotional messiness of relying on someone you barely know. Starring Annaleigh Ashford and Thomas Middleditch, the series leans on a high-concept medical premise but plays it as a warm character comedy about second chances, unlikely friendship, and the weird ways people show up for each other. The show premiered on CBS in November 2020 and ran through 2022.

Critical response to B Positive was generally mixed to positive, with reviewers often praising the cast more than the sitcom formula itself. Rotten Tomatoes' season-one consensus says the show's familiar sitcom trappings are lifted by its charming cast, especially Annaleigh Ashford's oddball, winsome comic energy. Rotten Tomatoes reports an 87% approval rating with an average score around 6.1/10 based on early reviews, while Metacritic's summary was more restrained, describing the pilot as decent enough in the CBS sitcom lane. Reviewers repeatedly singled out Ashford as the standout, and some noted that she and Middleditch worked well together as an immediate comic duo. Audience response was more divided, but the show's IMDb rating of 6.3/10 suggests a modestly positive reception overall rather than a breakout hit. In short, critics tended to appreciate the heart, premise, and performances, even when they felt the humor stayed safely within conventional network-comedy bounds.